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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Trial design and conduct

Early stopping

Termination of a trial before its planned completion, most often for efficacy at an interim analysis. Trials stopped early for efficacy systematically overestimate effect size, and the Institute…

Document identifier
CEI-GT-057
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Early stopping

§1.2Category

Trial design and conduct — Terms describing how a clinical study is constructed and run.

§1.3Related terms

  • Data monitoring committee — An independent group with access to unblinded accumulating data, empowered to recommend modification or termination. Its recommendation to stop for efficacy is a source…
Compound Evidence Institute · CEI-GT-057 · https://compoundevidence.com/glossary/early-stopping/ · retrieved 30 July 2026
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