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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Evidence assessment

Inconsistency

Unexplained variation in effect estimates across contributing studies, beyond what chance would produce. Consistency of direction with variation in magnitude is treated differently from variation in…

Document identifier
CEI-GT-013
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Inconsistency

§1.1Also known as

Heterogeneity

§1.2Category

Evidence assessment — Terms describing how the Institute judges and reports the strength of evidence.

§1.3Related terms

  • Heterogeneity — Variation in effect estimates across studies beyond that expected from chance. Quantified imperfectly by the I-squared statistic and assessed by inspection of the…
  • I-squared — The proportion of observed variation across studies attributable to heterogeneity rather than to chance. Does not indicate whether the heterogeneity matters, and takes…
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