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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Outcomes and endpoints

MACE

Major adverse cardiovascular events. Conventionally a three-point composite of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke; four- and five-point definitions exist and…

Document identifier
CEI-GT-093
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1MACE

§1.1Also known as

Major adverse cardiovascular events

§1.2Category

Outcomes and endpoints — Terms describing what a study measures and what the measurement supports.

§1.3Related terms

  • Composite endpoint — An endpoint counting the first occurrence of any of several component events. Interpretable only when the components are of comparable importance and move in the same…
  • Cardiovascular outcome trial — An event-driven trial with a composite cardiovascular endpoint, conducted for several agents in this class as a regulatory requirement to exclude excess risk. A trial…
Compound Evidence Institute · CEI-GT-093 · https://compoundevidence.com/glossary/mace/ · retrieved 30 July 2026
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