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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Outcomes and endpoints

Placebo-subtracted

An effect expressed as the difference between the change in the active arm and the change in the placebo arm. The only form in which the Institute reports a within-arm change.

Document identifier
CEI-GT-097
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Placebo-subtracted

§1.2Category

Outcomes and endpoints — Terms describing what a study measures and what the measurement supports.

§1.3Related terms

  • Placebo-controlled — A design in which the comparator is an inert preparation matched to the intervention in appearance and administration. Matching is imperfect where the intervention…
Compound Evidence Institute · CEI-GT-097 · https://compoundevidence.com/glossary/placebo-subtracted/ · retrieved 30 July 2026
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