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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Trial design and conduct

Randomised withdrawal

A design in which participants who have responded during an open-label lead-in are randomised to continue or to discontinue. Establishes whether an effect requires continued exposure to be maintained.

Document identifier
CEI-GT-042
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Randomised withdrawal

§1.1Also known as

Withdrawal design

§1.2Category

Trial design and conduct — Terms describing how a clinical study is constructed and run.

§1.3Related terms

  • Randomisation — The allocation of participants to study arms by a chance process, which distributes both known and unknown prognostic factors between arms in expectation. The single…
Compound Evidence Institute · CEI-GT-042 · https://compoundevidence.com/glossary/randomised-withdrawal/ · retrieved 30 July 2026
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