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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Evidence assessment

Upgrading

The increase of a certainty rating above its starting level, applicable in principle to observational evidence showing a large effect, a dose–response gradient or a plausible confounder that would…

Document identifier
CEI-GT-009
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Upgrading

§1.2Category

Evidence assessment — Terms describing how the Institute judges and reports the strength of evidence.

§1.3Related terms

  • Downgrading — The reduction of a certainty rating from its starting level because of a concern in one of five domains: risk of bias, inconsistency, indirectness, imprecision and…
Compound Evidence Institute · CEI-GT-009 · https://compoundevidence.com/glossary/upgrading/ · retrieved 30 July 2026
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