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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Pharmacology

Volume of distribution

The apparent volume into which a compound distributes, computed from dose and plasma concentration. A small value indicates confinement to the circulation, as expected for an albumin-bound peptide.

Document identifier
CEI-GT-110
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Volume of distribution

§1.1Also known as

Vd

§1.2Category

Pharmacology — Terms describing how a compound acts and how the body handles it.

§1.3Related terms

  • Plasma protein binding — The fraction of a compound bound to circulating protein and therefore not immediately available to distribute or be eliminated. Reversible albumin binding is the…
Compound Evidence Institute · CEI-GT-110 · https://compoundevidence.com/glossary/volume-of-distribution/ · retrieved 30 July 2026
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