Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Certainty index

Low certainty — page 2

Confidence in the effect estimate is limited. The true effect may be substantially different from the estimate.

Graded outcomes

52 documents · page 2 of 2

Table 1. Outcomes and syntheses graded at low certainty, on this page.

DocumentTypeEffect or conclusion as recorded
Thymosin beta-4 in cutaneous wound healing and tissue repair: effect on the anchor outcomeSynthesisLow certainty evidence from 3 contributing trials bears on the effect of Thymosin beta-4 on the anchor outcome for cutaneous wound healing and tissue repair. The estimate the Institute carries in the…
CJC-1295 in growth hormone deficiency and growth-hormone secretagogue pharmacology: effect on the anchor…SynthesisLow certainty evidence from 2 contributing trials bears on the effect of CJC-1295 on the anchor outcome for growth hormone deficiency and growth-hormone secretagogue pharmacology. The estimate the…
GHK-Cu in cutaneous wound healing and tissue repair: effect on the anchor outcomeSynthesisLow certainty evidence from 2 contributing trials bears on the effect of GHK-Cu on the anchor outcome for cutaneous wound healing and tissue repair. The estimate the Institute carries in the…
Maridebart cafraglutide in obesity and overweight in adults: effect on the anchor outcomeSynthesisLow certainty evidence from 2 contributing trials bears on the effect of Maridebart cafraglutide on the anchor outcome for obesity and overweight in adults. The estimate the Institute carries in the…
Petrelintide in obesity and overweight in adults: effect on the anchor outcomeSynthesisLow certainty evidence from 2 contributing trials bears on the effect of Petrelintide on the anchor outcome for obesity and overweight in adults. The estimate the Institute carries in the monograph…
Thymosin beta-4 in cutaneous wound healing and tissue repair: tolerability and discontinuationSynthesisLow certainty evidence from 3 contributing trials bears on tolerability. Discontinuation for adverse events is reported in the summary-of-findings table alongside the efficacy outcomes rather than in…
CJC-1295 in growth hormone deficiency and growth-hormone secretagogue pharmacology: tolerability and…SynthesisLow certainty evidence from 2 contributing trials bears on tolerability. Discontinuation for adverse events is reported in the summary-of-findings table alongside the efficacy outcomes rather than in…
GHK-Cu in cutaneous wound healing and tissue repair: tolerability and discontinuationSynthesisLow certainty evidence from 2 contributing trials bears on tolerability. Discontinuation for adverse events is reported in the summary-of-findings table alongside the efficacy outcomes rather than in…
Maridebart cafraglutide in obesity and overweight in adults: tolerability and discontinuationSynthesisLow certainty evidence from 2 contributing trials bears on tolerability. Discontinuation for adverse events is reported in the summary-of-findings table alongside the efficacy outcomes rather than in…
Petrelintide in obesity and overweight in adults: tolerability and discontinuationSynthesisLow certainty evidence from 2 contributing trials bears on tolerability. Discontinuation for adverse events is reported in the summary-of-findings table alongside the efficacy outcomes rather than in…
Thymosin beta-4 in cutaneous wound healing and tissue repair: durability of effectSynthesisLow certainty evidence bears on whether the effect of Thymosin beta-4 in cutaneous wound healing and tissue repair is maintained across the randomised period. The contributing trials range in…
CJC-1295 in growth hormone deficiency and growth-hormone secretagogue pharmacology: durability of effectSynthesisLow certainty evidence bears on whether the effect of CJC-1295 in growth hormone deficiency and growth-hormone secretagogue pharmacology is maintained across the randomised period. The contributing…

page 2 of 2

Nothing published by the Institute is medical advice, a diagnosis, a prescription, a treatment recommendation or a purchasing recommendation. Compounds supplied for research use are not approved for human or veterinary use in any jurisdiction, and a favourable analytical assessment of a supplier is not a statement that any product is safe or effective. The Institute publishes certainty ratings and never recommendations. No telephone number, messaging handle or ordering channel appears anywhere on this site.