Compound monographs in the registry
51 documents of type compound monograph.
Documents
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Endogenous pyridine dinucleotide coenzyme. NAD+ is the central redox coenzyme of intermediary metabolism and the substrate of the sirtuin and poly-ADP-ribose polymerase enzyme families. Tissue…
Very low23 Aug 2026 -
Oral non-peptide GLP-1 receptor agonist. Small-molecule GLP-1 receptor agonism with a short half-life requiring twice-daily administration. The Institute includes this monograph specifically…
Low20 Jul 2026 -
Amylin analogue, short-acting. Pramlintide reproduces the postprandial actions of endogenous amylin, which is deficient in insulin-deficient diabetes: it slows gastric emptying…
Moderate15 Jul 2026 -
Thymic peptide extract of undefined composition. Thymalin is a fractionated calf-thymus extract registered in the Russian Federation as an immunomodulator. Because its composition is not defined, no…
Very low15 Jul 2026 -
Dual glucagon and GLP-1 receptor agonist (oxyntomodulin analogue). Mazdutide reproduces the natural dual activity of oxyntomodulin with a pharmacokinetic profile suitable for weekly dosing. The glucagon arm…
Moderate22 Jun 2026 -
Growth-hormone-releasing hormone fragment analogue. Sermorelin stimulates pituitary growth-hormone release through the GHRH receptor. Its very short half-life confines the pharmacodynamic effect to a…
Low15 Jun 2026 -
Endogenous nonapeptide. DSIP was isolated on the hypothesis that it mediated sleep induction. Subsequent work has not established a receptor, a consistent pharmacological…
Very low24 May 2026 -
Octapeptide tight-junction regulator (zonulin antagonist). Larazotide antagonises zonulin-mediated tight-junction disassembly, reducing paracellular permeability in intestinal epithelium. The therapeutic…
Moderate07 May 2026 -
Endogenous tripeptide thiol antioxidant. Glutathione is the dominant intracellular low-molecular-weight thiol and the cofactor of the glutathione peroxidase and S-transferase systems…
Low06 May 2026 -
Oral non-peptide GLP-1 receptor partial agonist. Orforglipron activates the GLP-1 receptor from a non-peptide scaffold, producing the insulinotropic, glucagonostatic and central appetite effects of…
Moderate30 Apr 2026 -
37-residue cationic antimicrobial host-defence peptide. LL-37 permeabilises bacterial membranes through an amphipathic helical mechanism and separately acts as a chemoattractant and immunomodulator through…
Low27 Apr 2026 -
Synthetic ACTH(4-10) analogue heptapeptide. Semax is reported to increase expression of brain-derived neurotrophic factor and its receptor TrkB in rodent hippocampus, and to modulate…
Low19 Apr 2026 -
GLP-1 receptor agonist (exendin-based, short- and extended-release). Exenatide is a naturally DPP-4-resistant GLP-1 receptor agonist. The immediate-release presentation gives short, high peaks that produce a pronounced…
High17 Apr 2026 -
Growth-hormone secretagogue, selective ghrelin receptor agonist (pentapeptide). Ipamorelin activates the ghrelin receptor on pituitary somatotrophs, producing growth-hormone release through a pathway distinct from and…
Low20 Feb 2026 -
Synthetic tuftsin analogue heptapeptide. Selank is reported to produce anxiolysis without sedation or dependence, attributed to modulation of GABAergic transmission and to inhibition of…
Low09 Feb 2026 -
28-residue N-acetylated thymic polypeptide. Thymosin alpha-1 promotes T-lymphocyte differentiation and maturation, increases interleukin-2 and interferon-gamma production, and enhances…
Moderate23 Jan 2026 -
Copper(II)-complexed tripeptide. GHK is a naturally occurring tripeptide present in plasma at concentrations that decline with age. Complexed with copper it acts as a physiological…
Low08 Jan 2026 -
Small-molecule nicotinamide N-methyltransferase inhibitor. NNMT methylates nicotinamide, diverting it from NAD+ salvage and generating 1-methylnicotinamide. Inhibiting NNMT is proposed to raise cellular NAD+…
Very low07 Dec 2025 -
Dual glucagon and GLP-1 receptor agonist (acylated). Glucagon receptor agonism increases hepatic fatty-acid oxidation, resting energy expenditure and hepatic lipid clearance; GLP-1 receptor agonism…
Moderate19 Nov 2025 -
Acetylated heptapeptide fragment of thymosin beta-4. Thymosin beta-4 is an abundant intracellular actin-sequestering protein with reported extracellular activity in angiogenesis, cell migration and…
Very low13 Oct 2025 -
GLP-1 receptor agonist, Fc-fusion protein. Receptor pharmacology is that of the selective GLP-1 class, delivered from a large fusion protein. Because the molecule is above the renal filtration…
High23 Sep 2025 -
Growth-hormone secretagogue, non-selective ghrelin receptor agonist (hexapeptide). Ghrelin receptor agonism with pronounced growth-hormone release, marked appetite stimulation, and concomitant elevation of cortisol and…
Very low21 Sep 2025 -
Growth-hormone C-terminal fragment analogue. The proposed mechanism is stimulation of lipolysis and inhibition of lipogenesis in adipose tissue without the growth-hormone-receptor-mediated…
Very low17 Sep 2025 -
Mitochondrial-derived 16-residue peptide. MOTS-c is described as a mitochondrial-encoded regulator of metabolic homeostasis that acts through the folate one-carbon cycle to raise…
Very low20 Aug 2025 -
GLP-1 receptor agonist (cAMP-biased, acylated). Selective GLP-1 receptor agonism with a reported bias towards Gαs-coupled cyclic-AMP signalling. Whether signalling bias translates into a clinically…
Low27 Jun 2025 -
Endogenous decapeptide, KISS1 receptor agonist. Kisspeptin acts on KISS1 receptors on hypothalamic gonadotropin-releasing hormone neurons to stimulate GnRH secretion, and thereby luteinising…
Low11 Jun 2025 -
GIP receptor antagonist and GLP-1 receptor agonist conjugate (antibody–peptide). GLP-1 receptor agonism supplies appetite suppression; GIP receptor antagonism is proposed to act on adipose tissue and central pathways in…
Low19 May 2025 -
Long-acting amylin analogue. Amylin receptor agonism at the area postrema promoting meal-related satiation, with a formulation and half-life supporting weekly dosing. The…
Low20 Apr 2025 -
Mitochondria-targeted cardiolipin-binding tetrapeptide. Elamipretide binds cardiolipin in the inner mitochondrial membrane, stabilising cristae curvature and the assembly of electron-transport-chain…
Moderate17 Apr 2025 -
GLP-1 receptor agonist (exendin-based, short-acting). A short-acting prandial GLP-1 receptor agonist. Its dominant pharmacodynamic effect is marked slowing of gastric emptying, which produces substantial…
Moderate12 Apr 2025 -
Fixed-ratio combination of a long-acting amylin analogue and a GLP-1 receptor agonist. The combination pairs two complementary satiation mechanisms: GLP-1 receptor agonism acting on hypothalamic and hindbrain appetite…
Moderate24 Feb 2025 -
Long-acting amylin and calcitonin receptor agonist (acylated). Amylin is co-secreted with insulin and acts at the area postrema to promote meal-related satiation, and separately reduces gastric emptying and…
Moderate06 Feb 2025 -
Synthetic tetrapeptide. Epithalon is supplied on the premise that it activates telomerase and thereby extends replicative lifespan, on the basis of cell-culture reports of…
Very low26 Jan 2025 -
Dual GIP and GLP-1 receptor agonist (acylated). Tirzepatide engages both incretin receptors from a single molecule. GLP-1 receptor agonism reproduces the insulinotropic, glucagonostatic, gastric…
High16 Jan 2025 -
Non-selective melanocortin receptor agonist (cyclic heptapeptide). Melanotan-II is a potent non-selective melanocortin receptor agonist. MC1R agonism stimulates eumelanin synthesis in melanocytes, producing…
Very low02 Dec 2024 -
Growth-hormone-releasing hormone analogue. Tesamorelin stimulates the pituitary to release endogenous growth hormone in a pulsatile pattern, preserving the physiological feedback architecture…
Moderate01 Sep 2024 -
GLP-1 receptor agonist (acylated, once-daily). Receptor pharmacology is that of the selective GLP-1 class. The pharmacokinetic engineering differs: self-association into heptamers at the…
High27 Aug 2024 -
GLP-1 receptor agonist (acylated, long-acting). Semaglutide is a full agonist at the glucagon-like peptide-1 receptor, a class B G protein-coupled receptor signalling principally through Gαs and…
High16 Aug 2024 -
Melanocortin receptor agonist (cyclic heptapeptide). Bremelanotide activates central melanocortin-4 receptors, acting on hypothalamic and limbic circuits regulating sexual desire. Unlike…
Moderate15 Aug 2024 -
Unimolecular amylin and GLP-1 receptor co-agonist. A single peptide engineered to activate both the amylin and GLP-1 receptor systems, combining two complementary satiation mechanisms without the…
Low11 Aug 2024
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