Public comment period · §3
Draft monograph: GHRP-2 — disposition
The disposition of every submission and the amendments that resulted.
§3Disposition and amendments
§3.1Disposition table
Table 1. Every submission with its disposition. Each row links to the submission in full.
| Reference | Respondent | Point raised | Disposition |
|---|---|---|---|
| DRAFT-GHRP-2-MONOG/002 | Gaspard Kettlewell | Declared interests should appear on the document rather than on a separate page | Noted, no amendment |
| DRAFT-GHRP-2-MONOG/003 | Dr Hyacinth Drakeford-Amadi | Registered trials that never reported are absent from the monograph | Accepted |
| DRAFT-GHRP-2-MONOG/007 | Adaeze Underhill-Okafor | The analytical section is longer than the clinical assessment it accompanies | Accepted in part |
| DRAFT-GHRP-2-MONOG/006 | Dr Nikolai Yeovil-Bakare | The certainty rating for the principal assessed outcome cannot be traced to the contributing trials | Accepted |
| DRAFT-GHRP-2-MONOG/005 | Dr Evander Whitmarsh-Obi | Doses are expressed in units that differ between sections | Accepted |
| DRAFT-GHRP-2-MONOG/001 | Valentin Tollemache | A sortable table implies a comparison the underlying data do not support | Noted, no amendment |
| DRAFT-GHRP-2-MONOG/004 | Professor Bartolomeu Nkosi-Lindegaard | The monograph should not describe how the compound is supplied outside a regulated route | Noted, no amendment |
| 7 submissions in total. | |||
§3.2Summary by disposition
Table 2. Counts by disposition, with the meaning of each.
| Disposition | Count | Meaning |
|---|---|---|
| Accepted | 3 | The submission is accepted and the draft is amended as proposed. The amendment is recorded in the amendment log of the document it changed and is traceable to the numbered submission. |
| Accepted in part | 1 | Part of the submission is accepted and part is not. The secretariat response states which part is which and on what ground the remainder was declined. |
| Noted, no amendment | 3 | The submission raises a point the Institute accepts but that does not require a change to the draft, most often because the draft already states it elsewhere. The location is given in the response. |
| Not accepted | 0 | The submission is not accepted. The secretariat response gives the reason. A submission that is not accepted remains published in full; the Institute does not remove a submission because it disagrees with it. |
§3.3Resulting amendments
- Registered trials that never reported are absent from the monograph — arising from DRAFT-GHRP-2-MONOG/003. The trial list now includes every registered trial the Institute identified, with its reporting status stated, and the monograph reports the proportion of registered trials for which no result has been posted or published.
- The analytical section is longer than the clinical assessment it accompanies — arising from DRAFT-GHRP-2-MONOG/007. The analytical section is reduced to compound-specific content and cross-references the relevant standards for the general procedure, which shortens it substantially without removing what is not available elsewhere.
- The certainty rating for the principal assessed outcome cannot be traced to the contributing trials — arising from DRAFT-GHRP-2-MONOG/006. Each assessed outcome now carries its downgrade domains in the summary-of-findings row, with a short statement of the judgement made in each, so that the rating can be checked domain by domain against the contributing trials.
- Doses are expressed in units that differ between sections — arising from DRAFT-GHRP-2-MONOG/005. A single dose unit is now used throughout each monograph, with the source unit retained in parentheses wherever a conversion was applied, and every conversion is stated rather than performed silently.
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- International Organization for Standardization. ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories. ISO/IEC Standard 2017;3rd edition. identifier not held by the Institute
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.
Compound Evidence Institute · CEI-CP-051/3 · https://compoundevidence.com/comment-periods/draft-ghrp-2-monograph/disposition/ · retrieved 30 July 2026