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Document set current to 30 July 2026
Defined term · Pharmacology

Desensitisation

Reduction in receptor responsiveness following sustained stimulation, often through receptor internalisation. The pharmacological reason that non-pulsatile administration of a hypothalamic releasing…

Document identifier
CEI-GT-116
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Desensitisation

§1.2Category

Pharmacology — Terms describing how a compound acts and how the body handles it.

§1.3Related terms

  • Tachyphylaxis — Rapid attenuation of response with repeated administration. Documented for several growth-hormone secretagogues and material to any claim about sustained effect.
  • Biased agonism — Preferential activation of one signalling pathway over another from the same receptor. Proposed as a means of separating a desired effect from receptor internalisation…
Compound Evidence Institute · CEI-GT-116 · https://compoundevidence.com/glossary/desensitisation/ · retrieved 30 July 2026
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