Defined term · Evidence assessment
Indirectness
A mismatch between the population, intervention, comparator or outcome of the contributing studies and those of the question being answered. Also applied where an outcome that would answer the…
§1Indirectness
§1.2Category
Evidence assessment — Terms describing how the Institute judges and reports the strength of evidence.
§1.3Related terms
- Surrogate outcome — A measurement substituted for a clinical outcome on the assumption that a change in one predicts a change in the other. Validation of that assumption requires…
- Downgrading — The reduction of a certainty rating from its starting level because of a concern in one of five domains: risk of bias, inconsistency, indirectness, imprecision and…
Compound Evidence Institute · CEI-GT-011 · https://compoundevidence.com/glossary/indirectness/ · retrieved 30 July 2026