Defined term · Outcomes and endpoints
Surrogate outcome
A measurement substituted for a clinical outcome on the assumption that a change in one predicts a change in the other. Validation of that assumption requires trial-level evidence across…
§1Surrogate outcome
§1.1Also known as
Surrogate endpoint
§1.2Category
Outcomes and endpoints — Terms describing what a study measures and what the measurement supports.
§1.3Related terms
- Indirectness — A mismatch between the population, intervention, comparator or outcome of the contributing studies and those of the question being answered. Also applied where an…
- Clinical outcome — An outcome a person would notice or care about directly: death, an event, a symptom, a function. Distinguished throughout the document set from a surrogate.
Compound Evidence Institute · CEI-GT-090 · https://compoundevidence.com/glossary/surrogate-outcome/ · retrieved 30 July 2026