Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Methodology|Interests|Funding|Corrections
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Trial design and conduct

Intention to treat

Analysis of participants in the group to which they were randomised, regardless of the treatment they received. Preserves the comparison randomisation created and generally produces a more…

Document identifier
CEI-GT-051
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Intention to treat

§1.1Also known as

ITT

§1.2Category

Trial design and conduct — Terms describing how a clinical study is constructed and run.

§1.3Related terms

  • Per protocol — Analysis restricted to participants who adhered to the protocol. Breaks the randomised comparison and is reported by the Institute only as a secondary analysis alongside…
  • Estimand — A precise statement of the quantity a trial is estimating, including how intercurrent events such as discontinuation or rescue therapy are handled. Two trials reporting…
Compound Evidence Institute · CEI-GT-051 · https://compoundevidence.com/glossary/intention-to-treat/ · retrieved 30 July 2026
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