Indication assessment · Neuropsychiatric
Tobacco and nicotine dependence — indication assessment
Dependence on nicotine-containing products, characterised by craving, tolerance and withdrawal.
§1Assessment
§1.1Definition
Dependence on nicotine-containing products, characterised by craving, tolerance and withdrawal.
§1.2Anchor and additional outcomes
The Institute designates one anchor outcome per indication so that estimates for different compounds are reported on a common measure. The anchor for this indication is the first outcome below.
- Biochemically verified continuous abstinence
- Cigarettes per day
- Post-cessation weight change
§1.3State of the evidence
HighModerateLowVery low
No compound in the Institute's set has an assessed outcome in this indication. No compound is graded above low certainty in this indication, which the Institute records as the principal finding for it.
Compound Evidence Institute · CEI-IN-14 · https://compoundevidence.com/indications/addiction-nicotine/ · retrieved 30 July 2026