Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Indication assessment · §3

Biological ageing and healthspan endpoints — trial records

Trial records in the Institute's register bearing on biological ageing and healthspan endpoints.

Document identifier
CEI-IN-30/3
Series
Indication assessment
Version
2.2
Published
25 Jul 2026
Last reviewed
25 Jul 2026
Next review
25 Jul 2028
Identifier
10.71829/cei.ind.30
Certainty
Not rated
Cycle
2026 Q3
ICD-11
MG2A
Category
Other

§3Trials in this indication

4 trial records in the Institute's register bear on this indication, of which 1 is a published trial.

Table 2. Trial records bearing on biological ageing and healthspan endpoints.

RecordCompoundPhaseDesignRandomisedYear
EPI-RU-ELDERLYEpithalonObservational
EPI-RU-ELDERLY-PKprogramme recordEpithalonPhase 1Phase 1 ascending dose
EPI-RU-ELDERLY-RENAL-IMPprogramme recordEpithalonPhase 1Phase 1 ascending dose
EPI-RU-ELDERLY-BODY-COMPprogramme recordEpithalonRandomised, double-blind, placebo-controlled
This facet in the trial register.

References cited on this page

References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.

  1. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism 2015;21(3):443–454. doi:10.1016/j.cmet.2015.02.009 · PMID 25738459

Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.

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