Methodological standard · §5
CEI-MS-12 — system suitability and acceptance criteria
The performance the system must demonstrate, and the criteria a result must meet to be reportable.
§5System suitability and acceptance criteria
§5.1System suitability
Table 1. System suitability criteria. A determination is reportable only where every criterion is met at the time of analysis.
| Parameter | Criterion | What it establishes |
|---|---|---|
| Calibration correlation, each solvent | ≥ 0.99 | Curve linearity |
| Repeatability, six determinations at the limit | Relative standard deviation ≤ 15 % | Method precision |
| Signal-to-noise at the limit of quantitation | ≥ 10 | Sensitivity adequacy |
| Resolution between adjacent solvent pairs | ≥ 1.0 | Peak identification reliability |
§5.2Acceptance criteria
- Class 1 solvents must not exceed their individual concentration limits; benzene 2 ppm, carbon tetrachloride 4 ppm, 1,2-dichloroethane 5 ppm, 1,1-dichloroethene 8 ppm, 1,1,1-trichloroethane 1500 ppm.
- Class 2 solvents must not exceed their permitted daily exposure expressed as a concentration limit for the stated maximum daily dose.
- Where the synthesis route is not disclosed, a full screen is required and the non-disclosure is recorded on the report.
§5.3Limitations
Compound Evidence Institute · CEI-MS-12/5 · https://compoundevidence.com/methods/residual-solvents/acceptance-criteria/ · retrieved 30 July 2026