DSIP — compound monograph
Endogenous nonapeptide. Unapproved, research supply. The Institute assesses 3 outcomes for this compound and grades the strongest at very low certainty.
§1Identification and status
§1.1Nomenclature
- Preferred name
- DSIP
- Compound class
- Endogenous nonapeptide
- Assessment series
- Neuroactive peptides
- Synonyms and codes
- delta sleep-inducing peptide · Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu · DSIP nonapeptide
- Route as evaluated
- Subcutaneous, intravenous or intranasal in historical studies
§1.2Chemistry
Chemical identifiers are reproduced where they are public. Where a structure has not been published the monograph records not disclosed rather than constructing one.[1]
- CAS registry number
- 62568-57-4
- Molecular formula
- C35H48N10O15
- Average mass
- 848.81
- Monoisotopic mass
- 848.33
- ATC classification
- not assigned
§1.3Sequence and structural notes
A nonapeptide isolated in 1977 from the cerebral venous blood of rabbits during electrically induced sleep. Its name records the hypothesis under which it was found, which subsequent work has not confirmed.
§1.4Assessment status
The Institute assesses DSIP across 3 indications and grades the strongest of them at very low certainty. Supplied as a research chemical; no marketing authorisation for the uses under which it is supplied.
Table 1. Assessed outcomes for DSIP, ordered by certainty. Each row links to the per-indication evidence extract.
| Indication | Effect as recorded | Certainty | Trials |
|---|---|---|---|
| Alcohol use disorder | Small historical reports in withdrawal syndromes; not assessable | Very low | 0 |
| Cognitive performance and neuroprotection | No assessable evidence identified | Very low | 0 |
| Sleep initiation and maintenance disorders | Small historical studies reported inconsistent effects on sleep architecture; the effect that gave the peptide its name has not been reliably… | Very low | 1 |
| Effects are reproduced as the contributing trials reported them. Where a confidence interval is held it appears on the per-indication extract rather than in this summary table. | |||
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. ICH Q6B Specifications: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products. ICH Harmonised Tripartite Guideline 1999;Step 4 version. identifier not held by the Institute
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.