Mitochondrial and metabolic cofactors
Mitochondrial-derived peptides, cardiolipin-binding agents, redox cofactors and enzyme inhibitors.
Monographs in this series
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NNMT methylates nicotinamide, diverting it from NAD+ salvage and generating 1-methylnicotinamide. Inhibiting NNMT is proposed to raise cellular NAD+ and to reduce adipocyte lipogenesis. In diet-induced obese mice, 5-amino-1MQ…
Very low07 Dec 2025 -
CEI-MN-046Mitochondrial and metabolic cofactorsUnapproved, research supply3 assessed outcomesversion 1.3
Glutathione is the dominant intracellular low-molecular-weight thiol and the cofactor of the glutathione peroxidase and S-transferase systems. Administered glutathione is largely degraded extracellularly by gamma-glutamyl…
Low06 May 2026 -
CEI-MN-043Mitochondrial and metabolic cofactorsUnapproved, research supply4 assessed outcomesversion 1.0
MOTS-c is described as a mitochondrial-encoded regulator of metabolic homeostasis that acts through the folate one-carbon cycle to raise 5-aminoimidazole-4-carboxamide ribonucleotide and thereby activate AMP-activated protein…
Very low20 Aug 2025 -
CEI-MN-045Mitochondrial and metabolic cofactorsUnapproved, research supply4 assessed outcomesversion 2.1
NAD+ is the central redox coenzyme of intermediary metabolism and the substrate of the sirtuin and poly-ADP-ribose polymerase enzyme families. Tissue NAD+ declines with age in several species, which is the basis of interest in…
Very low23 Aug 2026 -
Elamipretide binds cardiolipin in the inner mitochondrial membrane, stabilising cristae curvature and the assembly of electron-transport-chain supercomplexes, and reducing cytochrome-c peroxidase activity. The result in…
Moderate17 Apr 2025