Assessment Committee

Contributes the analytical-characterisation sections of the monographs and reviews every submitted third-party report for method adequacy. She identified the systematic problem, recorded across several monographs, that…

Responsible for renal assessments, including the Institute's convention of reporting annual eGFR slope alongside any composite kidney endpoint on the ground that slope is less vulnerable to competing-risk distortion in…

Chairs assessments from which the Committee Chair is recused, which in practice means the entire incretin series. His contribution is the Institute's treatment of trials stopped early for efficacy: they are extracted in…

Responsible for adverse-event extraction and for the Institute's convention that an incidence figure is reported with the trial, dose and duration from which it comes, never as a bare percentage. She also authored the…

Responsible for the pharmacokinetic sections of the monograph series, including the decision to record explicitly where a parameter has not been characterised in humans rather than importing an animal value. He has…

Responsible for assessments in the neuropsychiatric indications, including the addiction and cognition groups. She authored the Institute's distinction between a low certainty rating arising from an absence of studies…

Responsible for every effect estimate and confidence interval the Institute reproduces, and for the rule that an estimate is reported on the scale on which it was measured before any standardisation. She insisted that…

Responsible for the sleep-apnoea assessments and for the observation, recorded in several documents, that centrally scored polysomnographic endpoints support a higher certainty rating than symptom-only respiratory…

Responsible for the search strategies underlying the synthesis series and for the requirement that every synthesis publish its search strings, database coverage and screening decisions in full, so that a reader can…

Chairs the committee that ratifies every certainty rating the Institute publishes. Her methodological position, applied consistently across the monograph series, is that an active-controlled non-inferiority result and a…

Responsible for the identification sections of the monograph series. Her rule, applied throughout, is that where a structure has not been published the monograph says "not disclosed" rather than reproducing an unsourced…