Evidence synthesis · §4
Delayed gastric emptying, residual gastric content and procedural sedation — summary of findings
Outcome-by-outcome summary with effect, certainty and the reason for each downgrade.
§4Summary of findings
§4.1Summary of findings
Table 7. Summary of findings for Delayed gastric emptying, residual gastric content and procedural sedation.
| Outcome | Participants (studies) | Effect as reported | Certainty | Reason for downgrade |
|---|---|---|---|---|
| Gastric emptying half-time by scintigraphy or breath testThe outcome the Institute designates as anchor for this indication. | — (0) | Low certainty evidence, almost entirely observational, indicates that residual gastric content is found more often in treated patients after a… | Low | publication bias |
| Discontinuation for adverse eventsReported as a summary-of-findings row rather than in a tolerability annex, following a public submission. | — (1) | No contributing study | Very low | indirectness |
| Serious adverse eventsEvent counts are low; the estimate is imprecise by construction. | — (1) | No contributing study | Very low | inconsistency, indirectness |
| Any adverse eventAscertained by spontaneous report in the contributing trials. | — (1) | No contributing study | Very low | risk of bias, imprecision |
| Residual gastric content at endoscopy or anaesthesiaA secondary outcome for this indication. Its hierarchical position within each contributing trial is recorded on that trial's abstract where the Institute holds it. | — (1) | Reported as a secondary outcome in a subset of contributing trials | Very low | risk of bias, publication bias |
| Gastrointestinal adverse-event incidenceA secondary outcome for this indication. Its hierarchical position within each contributing trial is recorded on that trial's abstract where the Institute holds it. | — (1) | Reported as a secondary outcome in a subset of contributing trials | Very low | risk of bias, imprecision, publication bias |
| Certainty ratings describe confidence in the effect estimate for the stated outcome. They are not recommendations and do not transfer between outcomes. | ||||
§4.2Certainty assessment for the anchor outcome
Table 8. Reasoning recorded against each certainty domain for the anchor outcome.
| Domain | Rating | Reasoning |
|---|---|---|
| Risk of bias | No concern | No serious concern identified in this domain. |
| Inconsistency | No concern | No serious concern identified in this domain. |
| Indirectness | No concern | No serious concern identified in this domain. |
| Imprecision | No concern | No serious concern identified in this domain. |
| Publication bias | Very serious | The evidence base is small, recent and wholly sponsor-generated. |
| Overall: Low certainty. Confidence in the effect estimate is limited. The true effect may be substantially different from the estimate. | ||
Compound Evidence Institute · CEI-ES-026/4 · https://compoundevidence.com/syntheses/gastroparesis-and-anaesthesia/summary-of-findings/ · retrieved 30 July 2026