Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Evidence synthesis · §5

Acute pancreatitis with incretin-based therapies — amendment log

Every change made since protocol registration, with its date and reason.

Document identifier
CEI-ES-025/5
Series
Evidence synthesis
Version
1.2
Published
22 Nov 2025
Last reviewed
22 Mar 2026
Next review
22 Sep 2027
Identifier
10.71829/cei.syn.25
Certainty
Moderate
Cycle
2025 Q4
Review type
Safety review
Search executed
04 Sep 2025

§5Amendment log

Every change made to this review after protocol registration is recorded below with its date and its reason. A change that is not in this log did not happen. The Institute publishes the log in full, including changes that did not alter a conclusion, because a reader cannot judge which changes matter unless all of them are visible.

§5.1Amendment log

Table 9. Amendments to this review since protocol registration.

DateVersionAmendmentRecord
07 Sep 20250.1Protocol registeredThe review protocol was registered with the Institute’s secretariat before the search was executed. No change to the review question was made after registration.
07 Nov 20251.1Certainty rating revisedThe certainty rating for one outcome was revised following the addition of a contributing study. The rationale is recorded in the certainty assessment section.
07 Jul 20261.2Search re-runThe search was re-run to the current cycle date. Newly identified records were screened against the registered criteria without modification of those criteria.
Current version 1.2, ratified in the 2025 Q4 assessment cycle.

§5.2Clinical study report requests

Table 10. Clinical study reports requested for the contributing trials, and the outcome of each request. Refusals are recorded because a review that does not record them presents the sponsor's disclosure decision as the Institute's own.

TrialRequestedOutcome
ESSENCE11 Jun 2025Refused
EXENATIDE-GE-PD08 Aug 2025No response
STRIDE24 Aug 2025Redirected to a data-access portal
SURMOUNT-531 Jul 2025No response
SURMOUNT-KOA07 Jun 2025No response
SURPASS-CVOT06 Jun 2025No response
FLOW22 Jun 2025No response
STEP-HFpEF-DM19 Jun 2025Redirected to a data-access portal

§5.3Superseded versions

Superseded versions of this review remain published at a stable address, are marked as superseded, and link forward to the current version. The current version links back to each of them. That practice was adopted following a submission that a document cited in the literature must remain retrievable in the form in which it was cited; the reasoning is published on the corrections policy disposition page.

References cited on this page

References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.

  1. Sodhi M, Rezaeianzadeh R, Kezouh A, Etminan M. Risk of gastrointestinal adverse events associated with glucagon-like peptide-1 receptor agonists for weight loss. JAMA 2023;330(18):1795–1797. doi:10.1001/jama.2023.19574 · PMID 37796527

Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.

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