Draft synthesis: Kidney outcomes with incretin receptor… — disposition

§3Disposition and amendments

§3.1Disposition table

Table 1. Every submission with its disposition. Each row links to the submission in full.

§3.2Summary by disposition

Table 2. Counts by disposition, with the meaning of each.

§3.3Resulting amendments

1. Regulatory assessment documents were not searched — arising from DRAFT-RENAL-OUTCOM/005. Published regulatory assessment documents are now searched as a named source, are reported as a distinct evidence class in the included-studies table, and contribute to the assessment while being excluded from pooled estimates where risk of bias could not be…
2. Overlapping primary studies across included reviews are counted more than once — arising from DRAFT-RENAL-OUTCOM/008. Overlap between included reviews is now assessed at primary-study level and reported in a citation matrix, and participant totals are reported for the union of primary studies rather than as a sum across reviews.
3. A single-trial result is presented in the visual form of a pooled estimate — arising from DRAFT-RENAL-OUTCOM/006. Outcomes contributed by a single trial are now reported without a pooled diamond, labelled as unreplicated, and downgraded for imprecision or inconsistency according to the framework rather than presented as a synthesis.
4. Registered trials that never reported are not counted anywhere in the review — arising from DRAFT-RENAL-OUTCOM/003. Registered trials without posted results are now identified, counted and reported as a distinct category in the screening flow, with the proportion of registered participants they represent stated in the limitations.
5. The choice of effect measure is not justified and changes the appearance of the result — arising from DRAFT-RENAL-OUTCOM/004. Every outcome now reports the relative effect and, where an assumed baseline risk can be stated and sourced, the corresponding absolute effect, with the baseline risk and its source given in the same row.
6. Subgroup findings are reported that were not registered in the protocol — arising from DRAFT-RENAL-OUTCOM/002. Every subgroup analysis is now labelled as pre-specified or post hoc against the registered protocol, post hoc analyses are reported in a separate subsection without a certainty rating, and the protocol version against which the labelling was made is stated.
7. The conclusion is stated more strongly than the certainty rating supports — arising from DRAFT-RENAL-OUTCOM/001. Conclusion wording is now drawn from a fixed set of formulations tied to the certainty rating, so that a low certainty rating produces a statement that the evidence may suggest an effect and that the estimate is likely to change with further research.
8. Results at materially different follow-up durations are pooled — arising from DRAFT-RENAL-OUTCOM/007. Estimates are now reported by duration band, with the number of contributing trials and participants in each band stated, and no estimate is pooled across bands.
9. A sponsor trial meeting the eligibility criteria was excluded — arising from DRAFT-RENAL-OUTCOM/010. The trial is added to the included set, the estimate and the certainty rating have been recomputed, and the screening record now states why the trial was missed, which was a database indexing gap rather than a screening judgement. The submission is identified…
10. Point estimates are given without an interval — arising from DRAFT-RENAL-OUTCOM/011. Every estimate now carries its interval where the source reported one, and where it did not, the estimate is annotated as reported without an interval rather than left to appear as a precise figure.
11. Doses differing several-fold are pooled without examining dose-response — arising from DRAFT-RENAL-OUTCOM/009. Estimates are now reported by dose group, a dose-response examination is reported where three or more dose levels contribute, and the pooled across-dose estimate is removed rather than retained alongside.

References cited on this page

References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.

1. International Organization for Standardization. ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories. ISO/IEC Standard 2017;3rd edition. identifier not held by the Institute

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