Consultations on evidence synthesis documents
33 consultations on documents of this type.
Consultations
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Consultation on the draft of this intervention review, which registers the question: What randomised evidence supports mitochondria-targeted peptides in primary mitochondrial disease and in age-related functional decline?
12 submissions1 not accepted -
Consultation on the draft of this analytical evidence review, which registers the question: How much does a reported chromatographic purity figure vary with the method used to obtain it?
4 submissions -
Consultation on the draft of this analytical evidence review, which registers the question: What is known about bacterial endotoxin content in peptides supplied for research and injected in practice?
2 submissions -
Consultation on the draft scoping review of change in lean mass during pharmacologically induced weight reduction. The review is scoping rather than an intervention review because the contributing studies measure body composition by…
7 submissions -
Consultation on the draft synthesis of incretin receptor agonists for metabolic dysfunction-associated steatohepatitis. The anchor outcome is histological, which raises the question the consultation was principally about: whether a…
12 submissions1 not accepted -
Consultation on the draft synthesis of incretin receptor agonists in adolescents. The contributing evidence is small, drawn principally from the adolescent arm of the STEP programme reported in the New England Journal of Medicine in 2022…
16 submissions2 not accepted -
Consultation on the second version of the synthesis of glucagon-like peptide-1 receptor agonists for weight reduction in adults with obesity. The revision re-runs the registered search, adds trials reported since the first version, and…
15 submissions1 not accepted -
Consultation on the draft of this network meta-analysis, which registers the question: In adults with obesity, does a multi-receptor incretin agonist produce a larger reduction in body weight than a single glucagon-like peptide-1 receptor…
7 submissions2 not accepted -
Consultation on the draft of this analytical evidence review, which registers the question: What is the effect of reconstitution practice on the dose actually delivered from a lyophilised research peptide?
9 submissions1 not accepted -
Consultation on the draft methodological review of transitivity in the incretin network. The review examines whether the trials connecting these interventions through common comparators are similar enough in population, background therapy…
9 submissions1 not accepted -
Consultation on the draft of this methodological review, which registers the question: What can be concluded from a development programme that was discontinued, and how should the Institute record it?
3 submissions1 not accepted -
Consultation on the draft of this scoping review, which registers the question: What clinical evidence supports the uses under which growth-hormone secretagogues are supplied for research?
9 submissions -
Consultation on the draft scoping review of melanocortin receptor agonists, which maps the evidence across approved indications and the uses for which these compounds are supplied outside a regulated route. The review is scoping because…
11 submissions1 not accepted -
Consultation on the draft safety review of delayed gastric emptying and residual gastric content in patients receiving an incretin receptor agonist who present for procedural sedation. The review assesses a signal drawn largely from…
15 submissions1 not accepted -
Consultation on the draft of this analytical evidence review, which registers the question: What proportion of certificates of analysis supplied with research peptides contain the fields required to interpret the reported purity figure?
8 submissions -
Consultation on the draft synthesis of weight trajectory after an incretin receptor agonist is stopped. The contributing evidence is drawn principally from the randomised withdrawal designs in STEP 4, reported in JAMA in 2021, and…
16 submissions2 not accepted -
Consultation on the draft analytical evidence review of published surveys of unregulated peptide supply. The review assesses what such surveys establish, and records that the great majority of them cannot establish the provenance of the…
14 submissions2 not accepted -
Consultation on the draft of this methodological review, which registers the question: To what extent does a change in body weight predict a change in the clinical outcomes for which weight reduction is undertaken?
9 submissions1 not accepted -
Consultation on the draft safety review of the rodent thyroid C-cell signal observed with glucagon-like peptide-1 receptor agonists and its relevance to humans. The review assesses the mechanistic evidence for a species difference in…
16 submissions -
Consultation on the draft of this scoping review, which registers the question: What randomised human evidence exists for BPC-157 in any indication?
4 submissions
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