Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial register facet

Phase 3 trial records

351 records at phase 3.

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Records

351 documents · page 1 of 15

Table 1. Trial records on this page. The table sorts on any column and filters on the controls above; both operate on the records shown on this page only.

RecordCompoundPhaseStatusDesignRandomisedYearCertainty
STRIDESemaglutidePhase 3ReportedRandomised, double-blind, placebo-controlled7922025Moderate
ESSENCESemaglutidePhase 3ReportedRandomised, double-blind, placebo-controlled1,1972025Moderate
SOULSemaglutide, oralPhase 3ReportedEvent-driven cardiovascular outcome trial9,6502025Moderate
SURMOUNT-5TirzepatidePhase 3ReportedRandomised, open-label, active-controlled7512025High
SURMOUNT-KOATirzepatidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Low
SURPASS-CVOTTirzepatidePhase 3ReportedEvent-driven cardiovascular outcome trial13,2992025Moderate
ATTAIN-1OrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Moderate
ATTAIN-2OrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Not rated
ACHIEVE-1OrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Not rated
ACHIEVE-2OrforglipronPhase 3ReportedRandomised, double-blind, active-controlled2025Not rated
REDEFINE-1CagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled3,4172025Moderate
REDEFINE-2CagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled1,2062025Moderate
GLORY-1MazdutidePhase 3ReportedRandomised, double-blind, placebo-controlled6102025Moderate
ECNO-PH3-CN-OBESITYEcnoglutidePhase 3ReportedRandomised, double-blind, placebo-controlled6642025Low
ECNO-PH3-CN-T2DEcnoglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Not rated
EXENATIDE-GE-PDExenatidePhase 3ReportedRandomised, double-blind, placebo-controlled1942025Moderate
SURMOUNT-KOA-REGIONAL-JPprogramme recordTirzepatidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ATTAIN-1-REGIONAL-JPprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ATTAIN-2-ELDERLYprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ACHIEVE-1-REGIONAL-JPprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ACHIEVE-2-ELDERLYprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
REDEFINE-1-ADHERENCEprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedObservational2025Very low
REDEFINE-2-OLEprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedSingle-arm open-label2025Very low
STRIDE-QOLprogramme recordSemaglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low

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