Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Consultation record

Submissions accepted in part — page 4

Part of the submission is accepted and part is not. The secretariat response states which part is which and on what ground the remainder was declined.

Submissions

390 documents · page 4 of 13

Table 1. Submissions with this disposition, on this page.

ReferenceConsultationRespondentPoint raised
DRAFT-MASH-SYNTHES/005Draft synthesis: incretin receptor agonists for metabolic…Dr Perpetua Haverkamp-Diallo industryA sponsor trial meeting the eligibility criteria was excluded
DRAFT-MASH-SYNTHES/006Draft synthesis: incretin receptor agonists for metabolic…Dr Wojciech Kaltenbach-MensahA surrogate outcome is used as the anchor without validation evidence
DRAFT-MASH-SYNTHES/009Draft synthesis: incretin receptor agonists for metabolic…Dr Jozef Brandvold-AchterbergTwo included studies do not meet the registered eligibility criteria
DRAFT-MASH-SYNTHES/012Draft synthesis: incretin receptor agonists for metabolic…Dr Oisín RautavaaraCrossover trials are pooled with parallel-group trials without adjustment
DRAFT-ADOLESCENT-S/001Draft synthesis: incretin receptor agonists in adolescentsProfessor Bartolomeu Nkosi-LindegaardRegulatory assessment documents were not searched
DRAFT-ADOLESCENT-S/012Draft synthesis: incretin receptor agonists in adolescentsDr Kolawole Isaksen-BalogunPoint estimates are given without an interval
DRAFT-ADOLESCENT-S/014Draft synthesis: incretin receptor agonists in adolescentsThaddeus Isaksen-BalogunSubgroup findings are reported that were not registered in the protocol
DRAFT-ANALYTICAL-S/009Draft analytical review: surveys of unregulated peptide supplyDr Séverine Oduya-KaltenbrunnerWhat the contributing methods could not have detected is not stated
DRAFT-ANALYTICAL-S/012Draft analytical review: surveys of unregulated peptide supplyDr Vittoria QuintanilhaThe search was limited by publication date and the limit is not justified
DRAFT-REGISTRY-STR/001Draft structure of the document registryDr Leonhard QuennevilleThe anchor outcome for an indication is not the outcome a decision turns on
DRAFT-REGISTRY-STR/008Draft structure of the document registryDr Jerome PetrossianA surrogate anchor should not be permitted at all
DRAFT-TOOLS-DISCLA/007Draft terms for the Institute’s calculatorsDr Emiliana OllerenshawFunding should not be accepted from any party the Institute assesses
DRAFT-TOOLS-DISCLA/010Draft terms for the Institute’s calculatorsYolanda Norrington-BhattA four-week window is too short for a respondent without institutional support
DRAFT-TOOLS-DISCLA/012Draft terms for the Institute’s calculatorsQuentin Whitmarsh-ObiReferences should carry a persistent identifier for every cited source
DRAFT-TOOLS-DISCLA/017Draft terms for the Institute’s calculatorsDr Constança Glendinning-UcheThe secretariat answers submissions and is not itself named
DRAFT-ORFORGLIPRON/002Draft monograph: orforglipronDr Leonhard QuennevilleThe mechanism section is written with more confidence than the clinical section it precedes
DRAFT-METHODOLOGY-/001Draft methodology document, version 4Dr Vasilisa ImmelmannThe treatment of sponsor-conducted evidence is unworkable where all the evidence is…
DRAFT-METHODOLOGY-/003Draft methodology document, version 4Dr Oisín RautavaaraThe framework does not say when a concern warrants one level and when it warrants two
DRAFT-METHODOLOGY-/005Draft methodology document, version 4Ivo MountstephenReferences should carry a persistent identifier for every cited source
DRAFT-METHODOLOGY-/016Draft methodology document, version 4Dr Kolawole Isaksen-BalogunThe conditions for upgrading observational evidence are too permissive
DRAFT-METHODOLOGY-/018Draft methodology document, version 4Dr Ndidi Ravensworth-IlungaPreprints and conference abstracts are excluded categorically
DRAFT-METHODOLOGY-/020Draft methodology document, version 4Dr Yusuf Whitmarsh-ObiAutomated assistance in screening should be disclosed and validated
DRAFT-SUPPLIERS-CO/006Draft supplier comparison tableAmara VandergraafThe front matter delays the reader from reaching the assessment
DRAFT-SUPPLIERS-CO/008Draft supplier comparison tableYolanda Norrington-BhattA wide table is unusable on a telephone
DRAFT-SUPPLIERS-CO/010Draft supplier comparison tableThaddeus Isaksen-BalogunPoint estimates are given without an interval
DRAFT-RETATRUTIDE-/002Draft monograph: retatrutideDr Fenella Steenkamp-FerreiraThe interaction section lists mechanisms rather than interactions
DRAFT-RETATRUTIDE-/003Draft monograph: retatrutideDr Henrike JastrzębskaThe recorded evidence gaps omit outcomes a reader would consider material
DRAFT-RETATRUTIDE-/008Draft monograph: retatrutideDr Wolfram Quintanilha industryThe monograph should reproduce the approved labelling rather than paraphrase it
DRAFT-RETATRUTIDE-/012Draft monograph: retatrutideDr Leonhard QuennevilleThe mechanism section is written with more confidence than the clinical section it precedes
DRAFT-MELANOCORTIN/001Draft scoping review: melanocortin receptor agonistsDr Jozef Brandvold-AchterbergThe same concern is used to downgrade in two domains

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